[FaD] Team XPC Welcomes sao95!

[Gouki]

Saw you in the stats and thought that you deserved a proper welcome thread! Welcome Aboard! :D

How many cows ya got crunching for ya?

[sao95]

thanks, I've been thinking of seeing what it was all about for awhile, right now I have it on one machine but I might put it on the second, have some questions but it's late so I'll post them tomorrow :)

[mickwish]

:cool: Always nice see see some more machines added to crunching for the cause!! :D

Any questions ya have, fire away: it ain't late here yet! :p

What CPU's and OSes ya running it on? :)

Cheers
Mick

[sharder8]

Welcome into the light Sao, welcome into the light!! :D

Now ya' can post yer' ?'s and we'll keep Mick awake until he answers every last one of them! :p

Harder

[Justoverbroke]

Welcome sao95!
You've joined the best!
These guys are great!

[LAURENU2]

Welcome sao95!
Glad to have you here
You joined just in time to play the lotto here where you can win PRIZES or MONEY

[tgxiii]

Nice to see your name in gold, sao95!

Make sure you enter Lauren's lotto!

[serlv ( Zippy )]

Welcome to our team, sao95! Glad you've thrown your lot in with us. We can use all the help we can get. A very worthy cause and an extremely driven team.

[mickwish]

Originally posted by serlv ( Zippy )
and an extremely driven team. Shouldn't that be an xtremely driven team? :p :lol:

Cheers
Mick

[Twinkletoes]

Welcome to the team Sao95. Now buckle down to crunching full time, and stop spreading so much rubbish around in the Lounge - it's a time-consuming job picking it all up after you !!!
:ROF:

[Win2Kuser]

Welcome to THE #1 team Sao95, thanks for helping us keep it that way :D

[davidw]

Welcome to the team!

[Wizzard~Of~Ozz]

Welcome to the team sao, always good to see a new face :)

[PresterJohn]

cool beans. welcome to the team...glad to have ya! :)

[Plum Ugly]

Welcome to the team!

[gino x]

Welcome welcome to our great team >:)

[roadtech]

soa95, Welcome to the Asylum................:eek:

[sao95]

thanks for the welcome all (wiping a tear away) if I wouldn't known this was the way to get in the "in crowd " I would of done it awhile ago :D

joking aside here's my questions:

1) using asus probe and running think all night I've been monitoring my temp at a steady 54C for processor and 34C for mobo, is that an alright temp or too hot?

2) where it says "hits" for a job, what does that mean?

3) these molecules that it is running, what is it testing them for? what's the program doing?

I'm sure I'll have a few more questions later, but my mind is else where so I reserve the right to ask later
:)

[ThRoNkA]

Hits is how many unique properties it found. The more hits, the better your score.

The testing it putting them together to found unique properties (above).

54 is a bit high. Use a HLT processor cooler software or check your case fans and cpu fan. Might be running slower and need replacement. Its kinda hot but within specs.

[Cowboybooter]

Welcome aboard, sao95! Great to have you on board!

You earn points by CPU rating multiplied by time in hours, but hits are a kinda neat thing to get!

:)

Bob

[Gouki]

Originally posted by sao95
1) using asus probe and running think all night I've been monitoring my temp at a steady 54C for processor and 34C for mobo, is that an alright temp or too hot?

2) where it says "hits" for a job, what does that mean?

3) these molecules that it is running, what is it testing them for? what's the program doing?


1) What kind of proc do you have? I'm running a XP 3200+ OC'd to 2.27ghz (for now) and it's around 53C.

2) A hit (from what I understand) means that it found something useful. Ie, An "anti-cancer" property within the molecule. A job that has low (or no hits) is just as useful though. If there's really low hits then the powers that be will know that they aren't on the right track...and if there are a lot of hits, they'll know to keep going in the same direction.

3) You could probably find more information at the FaD website. That's www.findadrug.org or perhaps some of the other members here could explain it better.

At any rate...glad you're crunching! :D

[sao95]

oops, forgot, I'm running a 2500+ barton, on winxp

edit: 4 case fans with a dual fan on psu

[tgxiii]

Originally posted by sao95

1) using asus probe and running think all night I've been monitoring my temp at a steady 54C for processor and 34C for mobo, is that an alright temp or too hot?

2) where it says "hits" for a job, what does that mean?

3) these molecules that it is running, what is it testing them for? what's the program doing?
:)
1) Those temps sound fine to me, but another factor to consider would be your room temperature. Any idea what it is?

2) To expand on what others have said already, as I understand it hits are molecules that can bind on a receptor protein. I'll explain a bit more on #3. More hits does not equate to more points, though. Points are calculated by the amount of time your computer spent doing the job multiplied by the CPU rating.

3) I hope I'm right about this:

FaD downloads a job from the server. This job contains 100 molecules. FaD then makes 100 variants of each molecule, giving you a total of 10,100 molecules ( 100 * 100 = 10,000 variants, plus the original 100 gives you 10,100 ). Then, FaD analyzes each molecule to see if they have properties that allow them to bind on a particular protein. If a molecule exhibits these properties, it is counted as a hit. Once all the molecules have been tested, they are uploaded back to the server.

Anyone who knows, please correct me if I'm wrong. AFAIK from asking people who have been running FaD for a long time, this is the process.

Edit: Eeek! Fixed basic arithmetic mistake.

[Win2Kuser]

^^
3)
Can't get a lot closer than that :)
The jobs downloaded are not always 100 molecules though, they tend to vary from 90 to 100.

When looking for a bind, if Think cant find one, it will time out after a certain time which is (100*cpu rating) seconds I think, after this time it will move onto the next molecules.

hth

[tgxiii]

Ah, I didn't realize it was always 100 molecules. :taking note:

[brian0555]

Welcome sao95!

I've been knocked offline for around 24 hrs, and this is the first chance I could welcome you to this awesome team!

[Shyguy]

& this is the first time I noticed this thread, sorry!!!

But Yeah, Welcome to the BEST Team in the World!!!!!

Glad to have you aboard!!!

[Twiztid Truckie]

Welcome Friend! Sao, youve joined the right crowd, but if you wanna stay sane, dont listen to a thing TTWit says to ya...From what Ive viewed here at XPC, he seems to be a bit, well, um...CooCoo? LOL! Thanks for helping our output on the team. Every systems counts! Good luck here, and always, if any questions arrise, I KNOW that someone here can awnser them, so post away!

Your Pal,
Truckie:)

[Paul W]

Glad to see you on the team Sao95. Welcome. :)

[JSkorna]

Welcome to the #1 team.

[Twinkletoes]

Originally posted by ThRoNkA
...The more hits, the better your score...
Thronka, it would be helpful to new folks if you would delete that ASAP.

[mickwish]

I think TT has a point there, Thronka. :rolleyes:

Hits actually have nothing at all to do with the amount of points you get for processing a job. Points are a calculation of your CPU speed (called CPU rating) and time. The more work you do, the more points get awarded to you. Simple as that. :)

Hits are actually what it's all about, though. They are identifed potential target sites that can may just be what scientists need to cure diseases or at least provide better drug treatments. :cool:

There, TT, that make you feel better now?? :p

Cheers
Mick

[Win2Kuser]

I think what ThRoNkA meant was that generally the higher hitting jobs run for longer and thus give more points, but it could have been written a bit more clearly :p :)

[tgxiii]

It's generally true that more hits usually mean more points, but the HYV jobs some of us ran recently had 1000+ hits but completed really quickly.

[Twinkletoes]

Originally posted by mickwish
...Hits are actually what it's all about, though...There, TT, that make you feel better now??... NO NO and NO. It does NOT make me feel better. That was just as bad - well, coming from you, worse !!!

<sweet reasonable mode on>I think you have placed far far too much importance on getting "hits". By crunching ONE work unit and getting NO hits you have effectively eliminated 10100 molecules/sub-molecules from all further consideration for now and everafter. And that is maybe MORE useful that getting a couple of dozen hits ?

Or take all these HIV work units which are racking up over a 1000 hits a throw. What does that tell us, apart from that they are ALL likely to be interesting - or does it tell us that they are all equally uninteresting ??? IMHO as a simple sensible non-medical soul, it's the HIV jobs which get NO hits which are the most "interesting" ones at the moment.<sweet reasonable mode off>.

How's the hernia ? Hope it's not hurting too much ! :D

[mickwish]

Originally posted by Twinkletoes
How's the hernia ? Hope it's still hurting a little bit ! Sweet and reasonable, eh? :rolleyes:

You have a point, though: we need to eliminate those sites on mollies that don't bind as well as find those that do. But I ain't gonna get excited by no hit jobs, really. Imagine: woo hoo!! I found nothing interesting!! :p

And, just because a job only gets a few hits doesn't mean it's possibly not a big find!! Every hit is important. And, yes, every non-hit is important, too: just not as exciting, IMO. Like waiting for paint to dry. Not much fun, but ya gotta do it to complete the job. ;)

Cheers
Mick

[Twinkletoes]

LOL !!! I just had a fit of remorse about that "Hope it's hurting" quip, rushed in from raking apples ín the garden, edited it, and then found you had already posted quoting it !!! Ah well ! You know me well enough to know it was not meant really seriously - only a little bit !!!

[mickwish]

It's all in fun, TT! :bunny: Like Harder in Lisa's Calendar Girl thread at FAD... :p

Doesn't hurt quite so much to laugh, today, so it's not too bad. ;)

Fit of remorse whilst raking apples, eh? That must mean something significant, but I just can't fathom what right now... :D

Cheers
Mick

[Twinkletoes]

Originally posted by mickwish
... But I ain't gonna get excited by no hit jobs, really. Imagine: woo hoo!! I found nothing interesting... Yeah, I can understand that some people - such as ahem! yourself - don't find them very exciting. But there are others of us in this wild wicked world - the more talented and gifted ones - who like to get things "finished", once and for all. OK, those no-hits mollies can be put in the archives, thrown out of the window, or put in Sharder's slop bucket for his next meal, sort of thing.

Try and think of it as being like the orgasm one gets from striking something off a list of "things to do"....



PS. To put you out of your misery - don't what to strain your grey cell - there was nothing sinister in "raking apples". I find it the easiest way to get rid of them: rake them up, load them into a wheelbarrow and dump them on the compost. Absolutely ridiculous considering the hungry kids in other parts of the world.

[mickwish]

Originally posted by Twinkletoes
"finished", once and for all Actually, just to put "finished" in perspective, some of the jobs we recently "finished" had been previously run at UD (Grid), apparently. Our current client is much better at finding hits than it's precedessor. ;)

Cheers
Mick

[tgxiii]

Isn't it when a particular query gets lots of hits, it gets run again a second time to try and reduce that amount? Like the 1A30 HIV mollies. There was Q1 where some people were getting 1000+ hits, then Q2 had to be run to try and reduce that amount. Or am I wrong? :confused:

[sao95]

I was thinking about it the other day after I read the posts here and my line of thought went along the same lines as TT's (scary huh? :) ) but deductive reasoning would say that we all believe there is a cure to be found through what we are doing and we all believe that because we are doing it, so the quickest way to find a cure would be to produce the least amount of hits as possible because it's less molecules to look at, which means the molecule that works will be found sooner, but then I went to fad and was reading in the forum for what think does and trader jim posted this



"I'm sure a more complete explanation is here somewhere, but in a nutshell, what your computer is doing is trying to fit various molecules into a certain niche in a protein. The niche, also called a "receptor site" is thought to contribute substantially to the natural progress of the disease. If we can find a molecule that fits well into the niche, it interferes with the progress of the disease.

Very clever algorithms are used to calculate the energy required to mash the molecule into (or pry it out of) the receptor site. If the molecule sticks to the receptor site very well, that configuration of the molecule may be a "hit". Molecules that have lots of hits are more likely to effect a disease than molecules with very few or no hits at all.

"This may sound somewhat crude, but I may have over simplified a bit. We think it's the best way to speed up the search for a cure for cancer, HIV, MS, Plague,and any number of other diseases and conditions."

so needless to say I'm confused again :confused: jim's post seems to suggest that when you download a molecule the more hits you get the better because it is the same molecule? so maybe what we're looking for is a molecule that gets tons and tons of hits, while all the other jobs get none??? :confused: :confused:
_________________

[tgxiii]

I think what confused you is when he said, "Molecules that have lots of hits." Well, it's not the molecules that have a lot of hits, it's the job. A job contains thousands of molecules. A molecule that exhibits very good properties of binding on a receptor site is a hit.

[Twinkletoes]

Originally posted by sao95
... If we can find a molecule that fits well into the niche, it interferes with the progress of the disease...Molecules that have lots of hits are more likely to effect a disease than molecules with very few or no hits at all.
That first sentence [of Trader Jim's] I wouldn't quarrel with. However I think that the all-important thing is what the geeks call the binding strength of the fit. Just because there are lots of hits I can not see why that should mean that they are all - or even one of them - is of high binding strength.

From my initial experiences as a kid with playing blocks, all the way up through my formal education as a god-knows-what (but part of it was studying the why:s and wherefore:s of the molecular strength of metal alloys), I've always found that a perfect fit is a perfect fit, and does not always have much bearing on what has occured immediately before, after, or in the vicinity. Sorry, that was very badly explained...

[draboo]

welcome mr 95;)

from sub-team R.R.M.

[tgxiii]

Originally posted by Twinkletoes
Just because there are lots of hits I can not see why that should mean that they are all - or even one of them - is of high binding strength.
Which is why some queries are run a second time, to get the best binders out of the good ones.

[Wizzard~Of~Ozz]

Actually a job could just have 1 very solid hit, and that's it, or it could have 3000 poor hits, which is relatively useless, so the number of hits is really moot, but 0 hits is also good as it eliminates that molecule from doing anything worth further exploration, the big picture is needed to see what binds very well, and also which does the most "blocking" (or starving the problemed cell)

[sao95]

a few more questions :)

what's a stoner? I'm guessing it's not what I knew a stoner to be from my youth :D

also do you have to send a job after it's complete each time or will it eventually do it itself?

[sharder8]

Originally posted by sao95
a few more questions :)

what's a stoner? I'm guessing it's not what I knew a stoner to be from my youth :D

also do you have to send a job after it's complete each time or will it eventually do it itself?

"stoner" = Someone who has just passed a milestone for Points, Mollies, Years, etc.

You do not have to send completed jobs in manually, they should upload based on your specified connection time. (ie. My connection is set of "when online", and since I'm on DSL, it uploads at completion.)

Harder

[Twinkletoes]

Originally posted by sharder8
....You do not have to send completed jobs in manually, they should upload based on your specified connection time. (ie. My connection is set of "when online", and since I'm on DSL, it uploads at completion.) Right click on the icon in the System Tray, select Set-Up and then under the General Tab you'll find "Internet Connection Plan" which you can fiddle around with.

I think that's what Sharder was trying to say...

[sao95]

thanks :)